Self-Control of HGF Regulation on Human Trophoblast Cell Invasion via Enhancing c-Met Receptor Shedding by ADAM10 and ADAM17 | Zendy

Yanyan Yang | Zendy; Yongqing Wang | Zendy; Xin Zeng | Zendy; Xiaojie Ma | Zendy; Yangyu Zhao | Zendy; Jie Qiao | Zendy; Bin Cao | Zendy; Yuxia Li | Zendy; Ji Lei | Zendy; Yanling Wang | Zendy

Open Access

Self-Control of HGF Regulation on Human Trophoblast Cell Invasion via Enhancing c-Met Receptor Shedding by ADAM10 and ADAM17

Author(s) -

Yanyan Yang,

Yongqing Wang,

Xin Zeng,

Xiaojie Ma,

Yangyu Zhao,

Jie Qiao,

Bin Cao,

Yuxia Li,

Ji Lei,

Yanling Wang

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2012-1150

Subject(s) - adam10 , trophoblast , hepatocyte growth factor , disintegrin , microbiology and biotechnology , metalloproteinase , receptor , medicine , biology , endocrinology , chemistry , placenta , matrix metalloproteinase , pregnancy , fetus , genetics

Hepatocyte growth factor (HGF)/c-Met signaling has been implicated in mammalian placental development. Integral c-Met can be released from endothelial cell membrane by proteolysis to form a soluble, truncated protein [soluble Met (sMet)], which is biochemically able to bind HGF and may disrupt HGF/c-Met signaling. By far, production of sMet in human placenta has not been reported, and the shedding mechanism remains unclear.

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