Somatostatin Analogs Modulate AIP in Somatotroph Adenomas: The Role of the ZAC1 Pathway
Author(s) -
Harvinder Chahal,
Giampaolo Trivellin,
Chrysanthia A. Leontiou,
Neda Alband,
Robert C. Fowkes,
Asil Tahir,
Susana Igreja,
J. Paul Chapple,
Susan J. Jordan,
Amelie Lupp,
Stefan Schulz,
Olaf Ansorge,
Niki Karavitaki,
Eivind Carlsen,
John Wass,
Ashley Grossman,
Márta Korbonits
Publication year - 2012
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2012-1111
Subject(s) - lanreotide , somatostatin , acromegaly , endocrinology , medicine , somatostatin receptor , octreotide , somatostatin receptor 2 , gene knockdown , apoptosis , biology , microbiology and biotechnology , cancer research , hormone , growth hormone , biochemistry
Somatotroph adenomas harboring aryl hydrocarbon receptor interacting protein (AIP) mutations respond less well to somatostatin analogs, suggesting that the effects of somatostatin analogs may be mediated by AIP.
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