Open AccessSerum Sclerostin and Risk of Hip Fracture in Older Caucasian Women
Author(s) -
Aarthi Arasu,
Peggy M. Cawthon,
LiYung Lui,
Thy P.,
Puneet Arora,
Jane A. Cauley,
Kristine E. Ensrud,
Steven R. Cummings
Publication year - 2012
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2011-3419
Subject(s) - sclerostin , medicine , quartile , hip fracture , confidence interval , cohort , bone mineral , body mass index , prospective cohort study , hazard ratio , cohort study , proportional hazards model , endocrinology , osteoporosis , biology , biochemistry , wnt signaling pathway , gene
Sclerostin, a protein secreted by osteocytes, inhibits bone formation. Individuals with genetic mutations that decrease the availability of sclerostin have very high bone mass.
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