Combination Treatment with T4 and T3: Toward Personalized Replacement Therapy in Hypothyroidism? | Zendy

Bernadette Biondi | Zendy; Leonard Wartofsky | Zendy

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Combination Treatment with T4 and T3: Toward Personalized Replacement Therapy in Hypothyroidism?

Author(s) -

Bernadette Biondi,

Leonard Wartofsky

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-3399

Subject(s) - levothyroxine , medicine , thyroid , hormone replacement therapy (female to male) , regimen , mood , quality of life (healthcare) , hormone therapy , triiodothyronine , pediatrics , endocrinology , testosterone (patch) , psychiatry , cancer , breast cancer , nursing

Levothyroxine therapy is the traditional lifelong replacement therapy for hypothyroid patients. Over the last several years, new evidence has led clinicians to evaluate the option of combined T(3) and T(4) treatment to improve the quality of life, cognition, and peripheral parameters of thyroid hormone action in hypothyroidism. The aim of this review is to assess the physiological basis and the results of current studies on this topic.

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