Differential Gene Expression by Oxyphil and Chief Cells of Human Parathyroid Glands | Zendy

Cynthia S. Ritter | Zendy; Bruce H. Haughey | Zendy; Brent Miller | Zendy; Alex J. Brown | Zendy

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Differential Gene Expression by Oxyphil and Chief Cells of Human Parathyroid Glands

Author(s) -

Cynthia S. Ritter,

Bruce H. Haughey,

Brent Miller,

Alex J. Brown

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-3366

Subject(s) - parathyroid chief cell , calcitriol receptor , paracrine signalling , calcium sensing receptor , autocrine signalling , medicine , endocrinology , calcimimetic , hyperparathyroidism , cinacalcet , parathyroid hormone , immunostaining , vitamin d and neurology , parathyroid gland , calcitriol , secondary hyperparathyroidism , receptor , calcium , immunohistochemistry

Parathyroid oxyphil cells, whose function is unknown, are thought to be derived from chief cells. Oxyphil cells increase in number in parathyroid glands of patients with chronic kidney disease (CKD) and are even more abundant in patients receiving treatment for hyperparathyroidism with calcitriol and/or the calcimimetic cinacalcet.

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