Features of Hepatic and Skeletal Muscle Insulin Resistance Unique to Type 1 Diabetes
Author(s) -
Bryan C. Bergman,
David Howard,
Irene E. Schauer,
David M. Maahs,
Janet K. SnellBergeon,
Robert H. Eckel,
Leigh Perreault,
Marian Rewers
Publication year - 2012
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2011-3172
Subject(s) - medicine , insulin resistance , endocrinology , insulin , diabetes mellitus , type 2 diabetes , type 1 diabetes , glucose clamp technique , carbohydrate metabolism , glucose uptake , pancreatic hormone
Type 1 diabetes is known to be a state of insulin resistance; however, the tissues involved in whole-body insulin resistance are less well known. It is unclear whether insulin resistance is due to glucose toxicity in the post-Diabetes Control and Complications Trial era of tighter glucose control.
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