High Frequency ofSERPINA6Polymorphisms that Reduce Plasma Corticosteroid-Binding Globulin Activity in Chinese Subjects | Zendy

Haiyan Lin | Zendy; Caroline Underhill | Zendy; Jinghui Lei | Zendy; Anna Helander-Claesson | Zendy; HwaYong Lee | Zendy; Bernd R. Gardill | Zendy; Yves A. Muller | Zendy; Hongmei Wang | Zendy; Geoffrey L. Hammond | Zendy

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High Frequency ofSERPINA6Polymorphisms that Reduce Plasma Corticosteroid-Binding Globulin Activity in Chinese Subjects

Author(s) -

Haiyan Lin,

Caroline Underhill,

Jinghui Lei,

Anna Helander-Claesson,

HwaYong Lee,

Bernd R. Gardill,

Yves A. Muller,

Hongmei Wang,

Geoffrey L. Hammond

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-3141

Subject(s) - transcortin , endocrinology , nonsynonymous substitution , medicine , snp , single nucleotide polymorphism , biology , exon , globulin , genetics , gene , genotype , genome

Cortisol is transported by corticosteroid-binding globulin (CBG) in blood. Single nucleotide polymorphisms (SNP) in the human CBG (SERPINA6) gene that disrupt CBG production or steroid binding are considered rare.

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