A High Percentage of BRAFV600E Alleles in Papillary Thyroid Carcinoma Predicts a Poorer Outcome | Zendy

Anna Guerra | Zendy; Laura Fugazzola | Zendy; Vincenzo Marotta | Zendy; Massimo Círillo | Zendy; Stefania Rossi | Zendy; Valentina Cirello | Zendy; Irene Forno | Zendy; Tania Moccia | Zendy; Alfredo Budillon | Zendy; Mario Vitale | Zendy

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A High Percentage of BRAFV600E Alleles in Papillary Thyroid Carcinoma Predicts a Poorer Outcome

Author(s) -

Anna Guerra,

Laura Fugazzola,

Vincenzo Marotta,

Massimo Círillo,

Stefania Rossi,

Valentina Cirello,

Irene Forno,

Tania Moccia,

Alfredo Budillon,

Mario Vitale

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-3106

Subject(s) - thyroid carcinoma , allele , medicine , odds ratio , metastasis , biology , thyroid cancer , context (archaeology) , carcinoma , genotype , oncology , gastroenterology , pathology , cancer , thyroid , genetics , gene , paleontology

BRAF(V600E) is considered a negative prognostic marker in papillary thyroid carcinoma (PTC), but unexplained conflicting results are present in the literature. In light of the new finding that most PTC consist of a mixture of tumor cells with wild-type and mutant BRAF, we examined the associations between the percentage of BRAF(V600E) alleles and both the clinicopathological parameters at time of diagnosis and the disease outcome in a large series of PTCs.

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