Metformin Improves Pregnancy and Live-Birth Rates in Women with Polycystic Ovary Syndrome (PCOS): A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial | Zendy

Laure MorinPapunen | Zendy; Anni S. Rantala | Zendy; Leila UnkilaKallio | Zendy; Aila Tiitinen | Zendy; Maritta Hippeläinen | Zendy; Antti Perheentupa | Zendy; Helena Tinkanen | Zendy; Risto Bloigu | Zendy; Katri Puukka | Zendy; Aimo Ruokonen | Zendy; Juha S. Tapanainen | Zendy

Open Access

Metformin Improves Pregnancy and Live-Birth Rates in Women with Polycystic Ovary Syndrome (PCOS): A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial

Author(s) -

Laure MorinPapunen,

Anni S. Rantala,

Leila UnkilaKallio,

Aila Tiitinen,

Maritta Hippeläinen,

Antti Perheentupa,

Helena Tinkanen,

Risto Bloigu,

Katri Puukka,

Aimo Ruokonen,

Juha S. Tapanainen

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-3061

Subject(s) - polycystic ovary , metformin , medicine , placebo , infertility , hazard ratio , pregnancy , miscarriage , pregnancy rate , live birth , population , gynecology , obstetrics , confidence interval , insulin , insulin resistance , biology , alternative medicine , environmental health , pathology , genetics

The role of metformin in the treatment of infertility in women with polycystic ovary syndrome (PCOS) is still controversial. OBJECTIVE AND OUTCOMES: We investigated whether metformin decreases the early miscarriage rate and improves the pregnancy rates (PR) and live-birth rates (LBR) in PCOS.

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