Microarray, qPCR, andKCNJ5Sequencing of Aldosterone-Producing Adenomas Reveal Differences in Genotype and Phenotype between Zona Glomerulosa- and Zona Fasciculata-Like Tumors | Zendy

Elena Azizan | Zendy; Brian Lam | Zendy; Stephen Newhouse | Zendy; Junhua Zhou | Zendy; Rhoda E. Kuc | Zendy; Jennifer Clarke | Zendy; Lisa Happerfield | Zendy; Alison Marker | Zendy; Gary J. Hoffman | Zendy; Morris J. Brown | Zendy

Open Access

Microarray, qPCR, andKCNJ5Sequencing of Aldosterone-Producing Adenomas Reveal Differences in Genotype and Phenotype between Zona Glomerulosa- and Zona Fasciculata-Like Tumors

Author(s) -

Elena Azizan,

Brian Lam,

Stephen Newhouse,

Junhua Zhou,

Rhoda E. Kuc,

Jennifer Clarke,

Lisa Happerfield,

Alison Marker,

Gary J. Hoffman,

Morris J. Brown

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2965

Subject(s) - biology , zona glomerulosa , laser capture microdissection , zona fasciculata , aldosterone , cyp17a1 , microarray analysis techniques , phenotype , genetics , gene expression , microbiology and biotechnology , medicine , endocrinology , gene , adrenal cortex , receptor , angiotensin ii

Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of somatic KCNJ5 mutations suggests a genetic explanation.

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