Filamin-A Is Essential for Dopamine D2 Receptor Expression and Signaling in Tumorous Lactotrophs | Zendy

Erika Peverelli | Zendy; Giovanna Mantovani | Zendy; Eleonora Vitali | Zendy; Francesca Marta Elli | Zendy; Luca Olgiati | Zendy; Stefano Ferrero | Zendy; Edward R. Laws | Zendy; Pamela Della Mina | Zendy; Antonello Villa | Zendy; Paolo BeckPeccoz | Zendy; Anna Spada | Zendy; Andrea Lania | Zendy

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Filamin-A Is Essential for Dopamine D2 Receptor Expression and Signaling in Tumorous Lactotrophs

Author(s) -

Erika Peverelli,

Giovanna Mantovani,

Eleonora Vitali,

Francesca Marta Elli,

Luca Olgiati,

Stefano Ferrero,

Edward R. Laws,

Pamela Della Mina,

Antonello Villa,

Paolo BeckPeccoz,

Anna Spada,

Andrea Lania

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2902

Subject(s) - flna , filamin , gene silencing , biology , dopamine receptor d2 , cancer research , prolactin , prolactin cell , microbiology and biotechnology , dopamine , endocrinology , genetics , cell , hormone , gene , cytoskeleton

Dopamine agonists (DA) are the first choice treatment of prolactinomas. However, a subset of patients is resistant to DA, due to undefined dopamine D2 receptor (D2R) alterations. Recently, D2R was found to associate with filamin-A (FLNA), a widely expressed cytoskeleton protein with scaffolding properties, in melanoma and neuronal cells.

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