A Stimulatory Thyrotropin Receptor Antibody Enhances Hyaluronic Acid Synthesis in Graves' Orbital Fibroblasts: Inhibition by an IGF-I Receptor Blocking Antibody | Zendy

Seema Kumar | Zendy; Seethalakshmi Iyer | Zendy; Hilary Bauer | Zendy; Michael J. Coenen | Zendy; Rebecca S. Bahn | Zendy

Open Access

A Stimulatory Thyrotropin Receptor Antibody Enhances Hyaluronic Acid Synthesis in Graves' Orbital Fibroblasts: Inhibition by an IGF-I Receptor Blocking Antibody

Author(s) -

Seema Kumar,

Seethalakshmi Iyer,

Hilary Bauer,

Michael J. Coenen,

Rebecca S. Bahn

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2890

Subject(s) - thyrotropin receptor , blocking antibody , antibody , receptor , hyaluronic acid , blocking (statistics) , chemistry , endocrinology , medicine , biochemistry , immunology , autoantibody , anatomy , statistics , mathematics

Graves' ophthalmopathy (GO) is characterized by expanded volume of the orbital fat and extraocular muscle tissues and elevated levels of TSH receptor autoantibodies (TRAb). The expansion of orbital tissues involves accumulation of hyaluronic acid (HA) within the orbit.

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