Insulin Up-Regulates Natriuretic Peptide Clearance Receptor Expression in the Subcutaneous Fat Depot in Obese Subjects: A Missing Link between CVD Risk and Obesity? | Zendy

Olga PivovarovaRamich | Zendy; Özlem Gögebakan | Zendy; Nora Klöting | Zendy; Andrea Sparwaßer | Zendy; Martin O. Weickert | Zendy; Isam Haddad | Zendy; Victoria J. Nikiforova | Zendy; Andreas Bergmann | Zendy; Michael Kruse | Zendy; Anne-Cathrin Seltmann | Zendy; Matthias Blüher | Zendy; A. Pfeiffer | Zendy; Natalia Rudovich | Zendy

Open Access

Insulin Up-Regulates Natriuretic Peptide Clearance Receptor Expression in the Subcutaneous Fat Depot in Obese Subjects: A Missing Link between CVD Risk and Obesity?

Author(s) -

Olga PivovarovaRamich,

Özlem Gögebakan,

Nora Klöting,

Andrea Sparwaßer,

Martin O. Weickert,

Isam Haddad,

Victoria J. Nikiforova,

Andreas Bergmann,

Michael Kruse,

Anne-Cathrin Seltmann,

Matthias Blüher,

A. Pfeiffer,

Natalia Rudovich

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2839

Subject(s) - medicine , endocrinology , adipose tissue , insulin , insulin resistance , type 2 diabetes , glucose clamp technique , diabetes mellitus , hyperinsulinemia , insulin receptor , glucose homeostasis , receptor , pancreatic hormone

Natriuretic peptides (NP) regulate cardiovascular homeostasis and have multiple metabolic properties. Decreased levels of NP or "natriuretic handicap" are signs of insulin resistance such as central obesity. Increased expression of NP clearance receptor (NPRC) in sc adipose tissue (SAT) was observed in insulin-resistant subjects.

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