Epidermal Growth Factor Induces Human Oviductal Epithelial Cell Invasion by Down-Regulating E-Cadherin Expression | Zendy

JungChien Cheng | Zendy; HsunMing Chang | Zendy; Peter C. K. Leung | Zendy

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Epidermal Growth Factor Induces Human Oviductal Epithelial Cell Invasion by Down-Regulating E-Cadherin Expression

Author(s) -

JungChien Cheng,

HsunMing Chang,

Peter C. K. Leung

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2751

Subject(s) - epidermal growth factor , biology , microbiology and biotechnology , protein kinase b , cadherin , small interfering rna , slug , cell culture , cancer research , cell , signal transduction , transfection , genetics

The loss of E-cadherin enhances cell invasiveness. There is increasing evidence that high-grade serous ovarian cancer may arise from oviductal epithelial cells rather than the ovarian surface epithelium. Despite the controversy over the cellular origins of this disease, the roles of epidermal growth factor (EGF) in human oviductal epithelial cells are largely unknown.

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