Orbit-Infiltrating Mast Cells, Monocytes, and Macrophages Produce PDGF Isoforms that Orchestrate Orbital Fibroblast Activation in Graves' Ophthalmopathy | Zendy

L. van Steensel | Zendy; Dion Paridaens | Zendy; Marjan van Meurs | Zendy; P. Martin van Hagen | Zendy; Willem A. van den Bosch | Zendy; Robert W. A. M. Kuijpers | Zendy; Hemmo A. Drexhage | Zendy; Herbert Hooijkaas | Zendy; Willem A. Dik | Zendy

Open Access

Orbit-Infiltrating Mast Cells, Monocytes, and Macrophages Produce PDGF Isoforms that Orchestrate Orbital Fibroblast Activation in Graves' Ophthalmopathy

Author(s) -

L. van Steensel,

Dion Paridaens,

Marjan van Meurs,

P. Martin van Hagen,

Willem A. van den Bosch,

Robert W. A. M. Kuijpers,

Hemmo A. Drexhage,

Herbert Hooijkaas,

Willem A. Dik

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2697

Subject(s) - platelet derived growth factor receptor , fibroblast , platelet derived growth factor , chemistry , growth factor , biology , microbiology and biotechnology , cell culture , receptor , biochemistry , genetics

Platelet-derived growth factors (PDGF) are regulators of fibroblast activity that may be involved in the pathophysiology of Graves' ophthalmopathy (GO). We unraveled the expression and origin of PDGF family members in GO orbital tissue and investigated the effect of PDGF isoforms on IL-6 and hyaluronan production and proliferation by orbital fibroblasts.

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