Impaired Incretin-Induced Amplification of Insulin Secretion after Glucose Homeostatic Dysregulation in Healthy Subjects | Zendy

Katrine Bagge Hansen | Zendy; Tina Vilsbøll | Zendy; Jonatan I. Bagger | Zendy; Jens J. Holst | Zendy; Filip K. Knop | Zendy

Open Access

Impaired Incretin-Induced Amplification of Insulin Secretion after Glucose Homeostatic Dysregulation in Healthy Subjects

Author(s) -

Katrine Bagge Hansen,

Tina Vilsbøll,

Jonatan I. Bagger,

Jens J. Holst,

Filip K. Knop

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2594

Subject(s) - incretin , medicine , endocrinology , insulin resistance , glucose homeostasis , glucagon like peptide 1 , homeostasis , type 2 diabetes , insulin , hormone , impaired glucose tolerance , diabetes mellitus , glucagon

The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.

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