Krüppel-Like Factor 9 and Progesterone Receptor Coregulation of Decidualizing Endometrial Stromal Cells: Implications for the Pathogenesis of Endometriosis | Zendy

John Mark P. Pabona | Zendy; Frank A. Simmen | Zendy; Mikhail A. Nikiforov | Zendy; Dazhong Zhuang | Zendy; Kartik Shankar | Zendy; Michael C. Velarde | Zendy; Zara Zelenko | Zendy; Linda C. Giudice | Zendy; Rosalia C.M. Simmen | Zendy

Open Access

Krüppel-Like Factor 9 and Progesterone Receptor Coregulation of Decidualizing Endometrial Stromal Cells: Implications for the Pathogenesis of Endometriosis

Author(s) -

John Mark P. Pabona,

Frank A. Simmen,

Mikhail A. Nikiforov,

Dazhong Zhuang,

Kartik Shankar,

Michael C. Velarde,

Zara Zelenko,

Linda C. Giudice,

Rosalia C.M. Simmen

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2562

Subject(s) - wnt signaling pathway , endometriosis , stromal cell , medicine , dkk1 , endocrinology , biology , cancer research , signal transduction , microbiology and biotechnology

Endometriosis is characterized by progesterone resistance and associated with infertility. Krüppel-like factor 9 (KLF9) is a progesterone receptor (PGR)-interacting protein, and mice null for Klf9 are subfertile. Whether loss of KLF9 expression contributes to progesterone resistance of eutopic endometrium of women with endometriosis is unknown.

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