Increased Expression of TSH Receptor by Fibrocytes in Thyroid-Associated Ophthalmopathy Leads to Chemokine Production | Zendy

Erin F. Gillespie | Zendy; K. Papageorgiou | Zendy; Roshini Fernando | Zendy; Nupur Raychaudhuri | Zendy; Kimberly Cockerham | Zendy; Laya K. Charara | Zendy; Allan Christian Pieroni Gonçalves | Zendy; Shuang-Xia Zhao | Zendy; Anna Ginter | Zendy; Ying Lu | Zendy; Terry J. Smith | Zendy; Raymond S. Douglas | Zendy

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Increased Expression of TSH Receptor by Fibrocytes in Thyroid-Associated Ophthalmopathy Leads to Chemokine Production

Author(s) -

Erin F. Gillespie,

K. Papageorgiou,

Roshini Fernando,

Nupur Raychaudhuri,

Kimberly Cockerham,

Laya K. Charara,

Allan Christian Pieroni Gonçalves,

Shuang-Xia Zhao,

Anna Ginter,

Ying Lu,

Terry J. Smith,

Raymond S. Douglas

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2514

Subject(s) - fibrocyte , medicine , chemokine , peripheral blood mononuclear cell , flow cytometry , immunology , cd14 , graves' disease , receptor , thyroid , pathology , endocrinology , biology , biochemistry , in vitro

The molecular basis for anatomically dispersed clinical manifestations in Graves' disease (GD) eludes our understanding. Bone marrow-derived, pluripotent fibrocytes represent a subset of peripheral blood mononuclear cells and infiltrate the orbital and thyroid tissues in GD. These cells may be involved in the pathogenesis of thyroid-associated ophthalmopathy (TAO).

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