Significance of IGFBP-4 in the Development of Fetal Growth Restriction | Zendy

Qing Qiu | Zendy; Michael D. Bell | Zendy; Xiaoyin Lu | Zendy; Xiaojuan Yan | Zendy; Marc Rodger | Zendy; Mark Walker | Zendy; Shi Wu Wen | Zendy; Shan Bainbridge | Zendy; Hongmei Wang | Zendy; Andrée Gruslin | Zendy

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Significance of IGFBP-4 in the Development of Fetal Growth Restriction

Author(s) -

Qing Qiu,

Michael D. Bell,

Xiaoyin Lu,

Xiaojuan Yan,

Marc Rodger,

Mark Walker,

Shi Wu Wen,

Shan Bainbridge,

Hongmei Wang,

Andrée Gruslin

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2511

Subject(s) - pregnancy , fetus , gestation , biology , endocrinology , placenta , syncytiotrophoblasts , medicine , pregnancy associated plasma protein a , andrology , fetal growth , western blot , first trimester , gene , genetics , biochemistry

Fetal growth restriction (FGR) is a leading cause of perinatal mortality and morbidity. Animal studies suggest dysregulation of IGF-binding protein (IGFBP)-4 is significant in the development of FGR, although human data are lacking. We postulated that IGFBP-4 is expressed at the maternal fetal interface and plays a role in regulating IGF bioavailability. Thus, maternal serum levels of IGFBP-4 may be associated with complications of abnormal placental growth and development including FGR.

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