Shorter Androgen Receptor CAG Repeat Lengths Associated with Cryptorchidism Risk among Hispanic White Boys
Author(s) -
Carol A. Davis-Dao,
Chester J. Koh,
Brian Hardy,
Andy Chang,
Steve Kim,
Roger De Filippo,
Andrew Hwang,
Malcolm C. Pike,
Joshua D. Carroll,
Gerhard A. Coetzee,
David J. Vandenberg,
Kimberly D. Siegmund,
Victoria K. Cortessis
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2011-2439
Subject(s) - androgen receptor , genotype , odds ratio , medicine , risk factor , androgen , biology , endocrinology , polyglutamine tract , gynecology , gastroenterology , genetics , gene , hormone , cancer , disease , prostate cancer , huntington's disease , huntingtin
Cryptorchidism is the most frequent congenital malformation among males, the major established risk factor for testicular germ cell tumors, and a presumed infertility risk factor. Androgens are essential for testicular descent, and functional genetic polymorphisms in the androgen receptor gene (AR) are postulated to influence cryptorchidism risk.
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