Melanocortin 2 Receptor-Associated Protein (MRAP) and MRAP2 in Human Adrenocortical Tissues: Regulation of Expression and Association with ACTH Responsiveness | Zendy

Johannes Hofland | Zendy; Patric J. D. Delhanty | Zendy; Jacobie Steenbergen | Zendy; Leo J. Hofland | Zendy; Peter M. van Koetsveld | Zendy; Francien H. van Nederveen | Zendy; Wouter W. de Herder | Zendy; Richard A. Feelders | Zendy; Frank H. de Jong | Zendy

Open Access

Melanocortin 2 Receptor-Associated Protein (MRAP) and MRAP2 in Human Adrenocortical Tissues: Regulation of Expression and Association with ACTH Responsiveness

Author(s) -

Johannes Hofland,

Patric J. D. Delhanty,

Jacobie Steenbergen,

Leo J. Hofland,

Peter M. van Koetsveld,

Francien H. van Nederveen,

Wouter W. de Herder,

Richard A. Feelders,

Frank H. de Jong

Publication year - 2012

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2328

Subject(s) - melanocortin , forskolin , endocrinology , medicine , receptor , adrenocorticotropic hormone , acth receptor , chemistry , biology , hormone

ACTH stimulates adrenocortical steroid production through the melanocortin 2 receptor (MC2R). MC2R trafficking and signaling are dependent on the MC2R accessory protein (MRAP). The MRAP homolog MRAP2 also transports the MC2R to the cell surface but might prevent activation.

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