Diurnal Rhythm of Circulating Nicotinamide Phosphoribosyltransferase (Nampt/Visfatin/PBEF): Impact of Sleep Loss and Relation to Glucose Metabolism | Zendy

Christian Benedict | Zendy; Anton Shostak | Zendy; Tanja Lange | Zendy; Samantha J. Brooks | Zendy; Helgi B. Schiöth | Zendy; Bernd Schultes | Zendy; Jan Born | Zendy; Henrik Oster | Zendy; Manfred Hallschmid | Zendy

Open Access

Diurnal Rhythm of Circulating Nicotinamide Phosphoribosyltransferase (Nampt/Visfatin/PBEF): Impact of Sleep Loss and Relation to Glucose Metabolism

Author(s) -

Christian Benedict,

Anton Shostak,

Tanja Lange,

Samantha J. Brooks,

Helgi B. Schiöth,

Bernd Schultes,

Jan Born,

Henrik Oster,

Manfred Hallschmid

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-2241

Subject(s) - endocrinology , nicotinamide phosphoribosyltransferase , medicine , postprandial , circadian rhythm , morning , carbohydrate metabolism , insulin , leptin , chemistry , obesity , nad+ kinase , biochemistry , enzyme

Animal studies indicate that nicotinamide phosphoribosyltransferase [Nampt/visfatin/pre-B-cell colony-enhancing factor (PBEF)] contributes to the circadian fine-tuning of metabolic turnover. However, it is unknown whether circulating Nampt concentrations, which are elevated in type 2 diabetes and obesity, display a diurnal rhythm in humans.

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