Open AccessDifferential Expression of the Androgen-Conjugating UGT2B15 and UGT2B17 Enzymes in Prostate Tumor Cells during Cancer Progression
Author(s) -
Sophie Pâquet,
Ladan Fazli,
Laurent Grosse,
Mélanie Verreault,
Bernard Têtu,
Paul S. Rennie,
Alain Bélanger,
Olivier Barbier
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2011-2064
Subject(s) - prostate cancer , androgen , lymph node , cancer research , prostate , medicine , oncology , cancer , endocrinology , biology , hormone
Androgens play major roles in prostate cancer initiation and development. In prostate cells, the human uridine diphosphate-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes inactivate androgens.
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