GLP-1 and Glucagon Secretion from a Pancreatic Neuroendocrine Tumor Causing Diabetes and Hyperinsulinemic Hypoglycemia
Author(s) -
Rachel Roberts,
Min Zhao,
Ben Whitelaw,
John Ramage,
Salvador J. DíazCano,
Carel W. le Roux,
Alberto Quaglia,
Guo Huang,
Simon Aylwin
Publication year - 2012
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2011-2005
Subject(s) - hyperinsulinemic hypoglycemia , medicine , endocrinology , glucagon , hypoglycemia , insulin , pancreas , islet , biology
Glucagon-like peptide-1 (GLP-1) is a gut peptide that promotes insulin release from pancreatic β-cells and stimulates β-cell hyperplasia. GLP-1 secretion causing hypoglycemia has been described once from an ovarian neuroendocrine tumor (NET) but has not been reported from a pancreatic NET (pNET).
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