Mitochondrial Fusion, Fission, and Biogenesis in Prolonged Critically Ill Patients | Zendy

Ilse Vanhorebeek | Zendy; Jan Gunst | Zendy; Sarah Derde | Zendy; Inge Derese | Zendy; Magaly Boussemaere | Zendy; André D’Hoore | Zendy; Pieter Wouters | Zendy; Greet Van den Berghe | Zendy

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Mitochondrial Fusion, Fission, and Biogenesis in Prolonged Critically Ill Patients

Author(s) -

Ilse Vanhorebeek,

Jan Gunst,

Sarah Derde,

Inge Derese,

Magaly Boussemaere,

André D’Hoore,

Pieter Wouters,

Greet Van den Berghe

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-1760

Subject(s) - mitochondrial biogenesis , mitochondrion , mitochondrial fission , mitochondrial fusion , medicine , endocrinology , skeletal muscle , insulin , biology , bioinformatics , microbiology and biotechnology , mitochondrial dna , biochemistry , gene

Critical illness induces swelling, enlargement, and dysfunction of mitochondria, which in liver, but not in muscle, is aggravated by excessive hyperglycemia. We previously demonstrated impaired autophagic clearance of damaged mitochondria in fed prolonged critically ill patients. Impaired fusion/fission-mediated repair and/or renewal through biogenesis may further accentuate mitochondrial abnormalities.

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