The Heterogeneity of Focal Forms of Congenital Hyperinsulinism | Zendy

Dunia Ismail | Zendy; Ritika R. Kapoor | Zendy; Virpi V. Smith | Zendy; Michael Ashworth | Zendy; Oliver Blankenstein | Zendy; Agostino Pierro | Zendy; Sarah E. Flanagan | Zendy; Sian Ellard | Zendy; Khalid Hussain | Zendy

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The Heterogeneity of Focal Forms of Congenital Hyperinsulinism

Author(s) -

Dunia Ismail,

Ritika R. Kapoor,

Virpi V. Smith,

Michael Ashworth,

Oliver Blankenstein,

Agostino Pierro,

Sarah E. Flanagan,

Sian Ellard,

Khalid Hussain

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-1628

Subject(s) - congenital hyperinsulinism , diazoxide , medicine , lesion , pancreas , hypoglycemia , hyperinsulinemic hypoglycemia , positron emission tomography , insulin , hyperinsulinism , pathology , nuclear medicine , insulin resistance

Congenital hyperinsulinism (CHI) is a cause of persistent hypoglycemia due to unregulated insulin secretion from pancreatic β-cells. Histologically, there are two major subgroups, focal and diffuse. Focal CHI is typically unresponsive to diazoxide and can be cured with surgical removal of the focal lesion.

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