Evaluation of the Sensitivity and Specificity of11C-Metomidate Positron Emission Tomography (PET)-CT for Lateralizing Aldosterone Secretion by Conn's Adenomas | Zendy

Timothy J. Burton | Zendy; Isla S. Mackenzie | Zendy; Kottekkattu Balan | Zendy; Brendan Koo | Zendy; Nick Bird | Zendy; Dmitry Soloviev | Zendy; Elena Azizan | Zendy; Franklin I. Aigbirhio | Zendy; Mark Gurnell | Zendy; Morris J. Brown | Zendy

Open Access

Evaluation of the Sensitivity and Specificity of¹¹C-Metomidate Positron Emission Tomography (PET)-CT for Lateralizing Aldosterone Secretion by Conn's Adenomas

Author(s) -

Timothy J. Burton,

Isla S. Mackenzie,

Kottekkattu Balan,

Brendan Koo,

Nick Bird,

Dmitry Soloviev,

Elena Azizan,

Franklin I. Aigbirhio,

Mark Gurnell,

Morris J. Brown

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-1537

Subject(s) - aldosterone , positron emission tomography , dexamethasone , medicine , nuclear medicine , hyperaldosteronism , adenoma , primary aldosteronism , endocrinology

Identification of unilateral aldosterone-producing (Conn's) adenomas has traditionally required lateralization by the invasive and technically difficult procedure of adrenal vein sampling (AVS). (11)C-metomidate, a potent inhibitor of adrenal steroidogenic enzymes, is a positron emission tomography (PET) radiotracer that is selectively accumulated by Conn's adenomas.

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