GDC-0941 Inhibits Metastatic Characteristics of Thyroid Carcinomas by Targeting both the Phosphoinositide-3 Kinase (PI3K) and Hypoxia-Inducible Factor-1α (HIF-1α) Pathways | Zendy

Natalie Burrows | Zendy; Muhammad Babur | Zendy; Julia Resch | Zendy; Sophie Ridsdale | Zendy; Melissa Mejin | Zendy; Emily J. Rowling | Zendy; Georg Brabant | Zendy; Kaye J. Williams | Zendy

Open Access

GDC-0941 Inhibits Metastatic Characteristics of Thyroid Carcinomas by Targeting both the Phosphoinositide-3 Kinase (PI3K) and Hypoxia-Inducible Factor-1α (HIF-1α) Pathways

Author(s) -

Natalie Burrows,

Muhammad Babur,

Julia Resch,

Sophie Ridsdale,

Melissa Mejin,

Emily J. Rowling,

Georg Brabant,

Kaye J. Williams

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-1426

Subject(s) - pten , tensin , pi3k/akt/mtor pathway , thyroid carcinoma , biology , endocrinology , cancer research , medicine , phosphoinositide 3 kinase , vascular endothelial growth factor , thyroid , signal transduction , microbiology and biotechnology , vegf receptors

Phosphoinositide 3-kinase (PI3K) regulates the transcription factor hypoxia-inducible factor-1 (HIF-1) in thyroid carcinoma cells. Both pathways are associated with aggressive phenotype in thyroid carcinomas.

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