Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind, Crossover Trial of LiothyronineVersusLevothyroxine | Zendy

Francesco S. Celi | Zendy; Marina Zemskova | Zendy; Joyce D. Linderman | Zendy; Susan M. Smith | Zendy; Bart E. Drinkard | Zendy; Vandana Sachdev | Zendy; Monica C. Skarulis | Zendy; Merel Kozlosky | Zendy; György Csákó | Zendy; Rene Costello | Zendy; Frank Pucino | Zendy

Open Access

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind, Crossover Trial of LiothyronineVersusLevothyroxine

Author(s) -

Francesco S. Celi,

Marina Zemskova,

Joyce D. Linderman,

Susan M. Smith,

Bart E. Drinkard,

Vandana Sachdev,

Monica C. Skarulis,

Merel Kozlosky,

György Csákó,

Rene Costello,

Frank Pucino

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-1329

Subject(s) - levothyroxine , euthyroid , context (archaeology) , medicine , endocrinology , thyroid , pediatrics , biology , paleontology

Levothyroxine (L-T(4)) therapy is based on the assumption that the conversion of T(4) into T(3) provides adequate amounts of active hormone at target tissues. However, in rodents, L-T(4) alone does not restore a euthyroid state in all tissues. Previous combination L-T(4)/liothyronine (L-T(3)) therapy trials focused on quality-of-life endpoints, and limited information is available on the effects on other measures of thyroid hormone action.

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