Maternal Cigarette Smoking and Effects on Androgen Action in Male Offspring: Unexpected Effects on Second-Trimester Anogenital Distance | Zendy

Paul Fowler | Zendy; Siladitya Bhattacharya | Zendy; Samantha Flannigan | Zendy; Amanda J. Drake | Zendy; Peter J. O’Shaughnessy | Zendy

Open Access

Maternal Cigarette Smoking and Effects on Androgen Action in Male Offspring: Unexpected Effects on Second-Trimester Anogenital Distance

Author(s) -

Paul Fowler,

Siladitya Bhattacharya,

Samantha Flannigan,

Amanda J. Drake,

Peter J. O’Shaughnessy

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-1100

Subject(s) - anogenital distance , gestation , offspring , androgen , fetus , pregnancy , in utero , endocrinology , medicine , physiology , biology , hormone , genetics

Fertility, sperm counts, and testis weights are reduced in men whose mothers smoked in pregnancy. Animal studies suggest this could be due to impaired androgen action. Anogenital distance (AGD) provides a readout of fetal androgen exposure and is reduced by in utero exposure to harmful chemicals in rodents. This study assessed whether maternal cigarette smoking disturbs AGD in the second trimester human fetus.

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