Catecholaminergic Axonal Varicosities Appear to Innervate Growth Hormone-Releasing Hormone-Immunoreactive Neurons in the Human Hypothalamus: The Possible Morphological Substrate of the Stress-Suppressed Growth | Zendy

Giorgio Rotoli | Zendy; George Grignol | Zendy; Walter Hu | Zendy; István Merchenthaler | Zendy; Bertalan Dudás | Zendy

Open Access

Catecholaminergic Axonal Varicosities Appear to Innervate Growth Hormone-Releasing Hormone-Immunoreactive Neurons in the Human Hypothalamus: The Possible Morphological Substrate of the Stress-Suppressed Growth

Author(s) -

Giorgio Rotoli,

George Grignol,

Walter Hu,

István Merchenthaler,

Bertalan Dudás

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-1069

Subject(s) - medicine , endocrinology , hypothalamus , tyrosine hydroxylase , neuropeptide y receptor , catecholaminergic , median eminence , dopamine , dopaminergic , biology , growth hormone–releasing hormone , chemistry , hormone , neuropeptide , receptor , growth hormone

Stress is considered to be a major factor in the regulation of growth. Psychosocial dwarfism, characterized with short stature, delayed puberty, and depression, is typically preceded by psychological harassment or stressful environment. It has been observed that stress suppresses GH secretion, possibly via the attenuation of GHRH secretion. However, the exact mechanism of the impact of stress on growth has not been elucidated yet.

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