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Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. Previous studies suggest that the higher risk observed in T allele carriers is due to endothelial dysfunction associated with a lower eNOS activity and that acute consumption of phenol-rich olive oil ameliorates postprandial endothelial dysfunction by reducing oxidative stress and increasing nitric oxide bioavailability. Nevertheless, how these facts may interact in a population with altered endothelial function such as metabolic syndrome patients remains unknown.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

NOS3 Glu298Asp Polymorphism Interacts with Virgin Olive Oil Phenols to Determine the Postprandial Endothelial Function in Patients with the Metabolic Syndrome