NOS3 Glu298Asp Polymorphism Interacts with Virgin Olive Oil Phenols to Determine the Postprandial Endothelial Function in Patients with the Metabolic Syndrome | Zendy

Ana Isabel Jiménez-Morales | Zendy; Juan Ruano | Zendy; Javier DelgadoLista | Zendy; Juan Marcelo Fernández | Zendy; Antonio Camargo | Zendy; Fernando LopezSegura | Zendy; Javier CaballeroVillarraso | Zendy; Francisco Fuentes | Zendy; José LópezMiranda | Zendy; Francisco PérezJiménez | Zendy

Open Access

NOS3 Glu298Asp Polymorphism Interacts with Virgin Olive Oil Phenols to Determine the Postprandial Endothelial Function in Patients with the Metabolic Syndrome

Author(s) -

Ana Isabel Jiménez-Morales,

Juan Ruano,

Javier DelgadoLista,

Juan Marcelo Fernández,

Antonio Camargo,

Fernando LopezSegura,

Javier CaballeroVillarraso,

Francisco Fuentes,

José LópezMiranda,

Francisco PérezJiménez

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-1056

Subject(s) - postprandial , olive oil , medicine , phenols , metabolic syndrome , function (biology) , endocrinology , polymorphism (computer science) , biology , food science , biochemistry , obesity , genetics , gene , genotype , insulin

Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. Previous studies suggest that the higher risk observed in T allele carriers is due to endothelial dysfunction associated with a lower eNOS activity and that acute consumption of phenol-rich olive oil ameliorates postprandial endothelial dysfunction by reducing oxidative stress and increasing nitric oxide bioavailability. Nevertheless, how these facts may interact in a population with altered endothelial function such as metabolic syndrome patients remains unknown.

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