Underestimation of Effect of Thyroid Function Parameters on Morbidity and Mortality due to Intra-Individual Variation | Zendy

Annenienke C. van de Ven | Zendy; Romana T. NeteaMaier | Zendy; Marco Medici | Zendy; Fred C.G.J. Sweep | Zendy; H A Ross | Zendy; Albert Hofman | Zendy; Jacqueline de Graaf | Zendy; Lambertus A. Kiemeney | Zendy; Ad R. Hermus | Zendy; Robin P. Peeters | Zendy; Theo J. Visser | Zendy; Martin den Heijer | Zendy

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Underestimation of Effect of Thyroid Function Parameters on Morbidity and Mortality due to Intra-Individual Variation

Author(s) -

Annenienke C. van de Ven,

Romana T. NeteaMaier,

Marco Medici,

Fred C.G.J. Sweep,

H A Ross,

Albert Hofman,

Jacqueline de Graaf,

Lambertus A. Kiemeney,

Ad R. Hermus,

Robin P. Peeters,

Theo J. Visser,

Martin den Heijer

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-0680

Subject(s) - thyroid function , medicine , thyroid disease , thyroid dysfunction , thyroid function tests , thyroid , population , variation (astronomy) , disease , demography , statistics , physiology , environmental health , mathematics , physics , sociology , astrophysics

Thyroid dysfunction is associated with several diseases and mortality. Due to the within-individual variation of TSH and free T(4) (FT(4)) levels, the association between thyroid function and disease or mortality rates might be underestimated in studies based on one single measurement of TSH and/or FT(4). This kind of bias is called regression dilution bias. The aim of this study was to examine the within-individual variability of TSH and FT(4) measurements several years apart in different study cohorts and to determine the magnitude of the underestimation of the association between thyroid function and disease rates in population-based studies using only one baseline measurement.

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