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Thyroid dysfunction is associated with several diseases and mortality. Due to the within-individual variation of TSH and free T(4) (FT(4)) levels, the association between thyroid function and disease or mortality rates might be underestimated in studies based on one single measurement of TSH and/or FT(4). This kind of bias is called regression dilution bias. The aim of this study was to examine the within-individual variability of TSH and FT(4) measurements several years apart in different study cohorts and to determine the magnitude of the underestimation of the association between thyroid function and disease rates in population-based studies using only one baseline measurement.

Underestimation of Effect of Thyroid Function Parameters on Morbidity and Mortality due to Intra-Individual Variation