2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans | Zendy

Katrine Bagge Hansen | Zendy; Mette M. Rosenkilde | Zendy; Filip K. Knop | Zendy; Niels Wellner | Zendy; Thi Ai Diep | Zendy; Jens F. Rehfeld | Zendy; Ulrik B. Andersen | Zendy; Jens J. Holst | Zendy; Harald S. Hansen | Zendy

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2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

Author(s) -

Katrine Bagge Hansen,

Mette M. Rosenkilde,

Filip K. Knop,

Niels Wellner,

Thi Ai Diep,

Jens F. Rehfeld,

Ulrik B. Andersen,

Jens J. Holst,

Harald S. Hansen

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-0647

Subject(s) - incretin , medicine , endocrinology , oleic acid , monoacylglycerol lipase , agonist , chemistry , glucagon like peptide 1 , fatty acid , receptor , biochemistry , biology , type 2 diabetes , endocannabinoid system , diabetes mellitus

Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.

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