Multiple Loci in the HLA Complex Are Associated with Addison's Disease | Zendy

Beate Skinningsrud | Zendy; Benedicte A. Lie | Zendy; Ewa Lavant | Zendy; Joyce Carlson | Zendy; M Kellis | Zendy; Hanne E. Akselsen | Zendy; Kristina Gervin | Zendy; Anette S. B. Wolff | Zendy; Martina M. Erichsen | Zendy; Kristian Løvås | Zendy; Eystein S. Husebye | Zendy; Dag E. Undlien | Zendy

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Multiple Loci in the HLA Complex Are Associated with Addison's Disease

Author(s) -

Beate Skinningsrud,

Benedicte A. Lie,

Ewa Lavant,

Joyce Carlson,

M Kellis,

Hanne E. Akselsen,

Kristina Gervin,

Anette S. B. Wolff,

Martina M. Erichsen,

Kristian Løvås,

Eystein S. Husebye,

Dag E. Undlien

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-0645

Subject(s) - odds ratio , human leukocyte antigen , haplotype , major histocompatibility complex , locus (genetics) , genetics , immunology , allele , biology , disease , medicine , gene , antigen

A strong association between autoimmune Addison's disease (AAD) and major histocompatibility complex class II-encoded HLA-DRB1-DQA1-DQB1 haplotypes is well known. Recent evidence from other autoimmune diseases has suggested that class I-encoded HLA-A and HLA-B gene variants confer HLA-DRB1-DQA1-DQB1-independent effects on disease.

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