The Effect of Common Genetic Variation in 11β-Hydroxysteroid Dehydrogenase Type 1 on Hypothalamic-Pituitary-Adrenal Axis Activity and Incident Depression | Zendy

Marieke J. H. J. Dekker | Zendy; Henning Tiemeier | Zendy; Hendrika J. Luijendijk | Zendy; Maris Kuningas | Zendy; Roelande Hofman | Zendy; Frank H. de Jong | Zendy; Paul M. Stewart | Zendy; J. W. Koper | Zendy; Steven W. J. Lamberts | Zendy

Open Access

The Effect of Common Genetic Variation in 11β-Hydroxysteroid Dehydrogenase Type 1 on Hypothalamic-Pituitary-Adrenal Axis Activity and Incident Depression

Author(s) -

Marieke J. H. J. Dekker,

Henning Tiemeier,

Hendrika J. Luijendijk,

Maris Kuningas,

Roelande Hofman,

Frank H. de Jong,

Paul M. Stewart,

J. W. Koper,

Steven W. J. Lamberts

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-0601

Subject(s) - medicine , endocrinology , single nucleotide polymorphism , androstenedione , population , hydrocortisone , biology , hormone , genotype , genetics , androgen , environmental health , gene

Accumulating evidence suggests that hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA axis) is involved in depression. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inert cortisone to active cortisol and is implicated in HPA axis regulation in animal studies. The aim of our study was to identify polymorphisms in 11β-HSD1 gene (HSD11B1) with consistent associations with increased HPA axis activity and relate those polymorphisms to depression.

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