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Accumulating evidence suggests that hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA axis) is involved in depression. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inert cortisone to active cortisol and is implicated in HPA axis regulation in animal studies. The aim of our study was to identify polymorphisms in 11β-HSD1 gene (HSD11B1) with consistent associations with increased HPA axis activity and relate those polymorphisms to depression.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

The Effect of Common Genetic Variation in 11β-Hydroxysteroid Dehydrogenase Type 1 on Hypothalamic-Pituitary-Adrenal Axis Activity and Incident Depression