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Change in Undercarboxylated Osteocalcin Is Associated with Changes in Body Weight, Fat Mass, and Adiponectin: Parathyroid Hormone (1-84) or Alendronate Therapy in Postmenopausal Women with Osteoporosis (the PaTH Study)
Author(s) -
Anne L. Schafer,
Deborah E. Sellmeyer,
Ann V. Schwartz,
Clifford J. Rosen,
Eric Vittinghoff,
Lisa Palermo,
John P. Bilezikian,
Dolores Shoback,
Dennis M. Black
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2011-0587
Subject(s) - endocrinology , medicine , osteocalcin , parathyroid hormone , osteoporosis , adiponectin , bone remodeling , leptin , obesity , chemistry , insulin resistance , alkaline phosphatase , calcium , enzyme , biochemistry
The undercarboxylated form of the osteoblast-secreted protein osteocalcin has favorable effects on fat and glucose metabolism in mice. In human subjects, cross-sectional studies suggest a relevant association.

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