Autocrine Proliferative Effects of hGH Are Maintained in Primary Cultures of Human Mammary Carcinoma Cells
Author(s) -
Jean Chiésa,
Catherine Ferrer,
Cécile Arnould,
Cécile M. Vouyovitch,
JeanJacques Diaz,
S. Gonzalez,
P. Marès,
Gérard Morel,
Zhengsheng Wu,
Tao Zhu,
Peter E. Lobie,
Hichem C. Mertani
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2011-0473
Subject(s) - autocrine signalling , endocrinology , medicine , biology , receptor , cell culture , cell growth , paracrine signalling , stimulation , biochemistry , genetics
Empirical evidence suggests that autocrine human GH (hGH) may possess a proliferative and oncogenic role in human mammary carcinoma. However, this concept is largely derived from studies using cultured human mammary carcinoma cell (HMCC) lines.
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