Open AccessSmad2:A Candidate Gene for the Murine Autoimmune Diabetes LocusIdd21.1
Author(s) -
Sarah Hook,
Amanda PhippsGreen,
Fathimath Faiz,
Les McNoe,
Cushla McKinney,
Jade E. HollisMoffatt,
Tony R. Merriman
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2011-0463
Subject(s) - nod , nod mice , congenic , biology , immune system , adoptive cell transfer , immunology , t cell , gene , genetics
Congenic NOD.ABH(D18Mit8-D18Mit214) mice, which contain greater than 12.8 Mb of DNA encompassing Idd21.1 from diabetes-resistant Biozzi/ABH mice, have a lower frequency of diabetes compared with the parental nonobese diabetic (NOD) strain, possibly due to reduced pathogenicity of β-islet-infiltrating immune cells.
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