Association of the Pro12Ala and C1431T Variants ofPPARγ and Their Haplotypes with Susceptibility to Gestational Diabetes | Zendy

Barbara Heude | Zendy; Véronique Pelloux | Zendy; Anne Forhan | Zendy; JeanFrançois Bedel | Zendy; JeanMarc Lacorte | Zendy; Karine Clément | Zendy; MarieAline Charles | Zendy

Open Access

Association of the Pro12Ala and C1431T Variants ofPPARγ and Their Haplotypes with Susceptibility to Gestational Diabetes

Author(s) -

Barbara Heude,

Véronique Pelloux,

Anne Forhan,

JeanFrançois Bedel,

JeanMarc Lacorte,

Karine Clément,

MarieAline Charles

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-0381

Subject(s) - gestational diabetes , linkage disequilibrium , type 2 diabetes , haplotype , diabetes mellitus , medicine , allele , context (archaeology) , polymorphism (computer science) , endocrinology , pregnancy , genetics , gestation , biology , gene , paleontology

The protective role of the Ala allele in the Pro12Ala polymorphism of PPARγ on type 2 diabetes has been well established but not confirmed in the context of pregnancy, for gestational diabetes, a known predictor of later type 2 diabetes onset. Another PPARγ polymorphism, the C1431T, is in strong linkage disequilibrium with Pro12Ala and has been shown to be associated with body weight, but its association with diabetes is controversial.

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