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Effects of Pioglitazone on Renal Calcium Excretion
Author(s) -
Anne Zanchi,
Antoinette Péchère-Bertschi,
Michel Burnier,
Olivier Bonny
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2011-0373
Subject(s) - pioglitazone , endocrinology , medicine , excretion , calcium , chemistry , renal sodium reabsorption , renal function , renal physiology , urinary calcium , reabsorption , hypercalciuria , type 2 diabetes , diabetes mellitus , kidney
Glitazones increase fracture risk in long-term users and in postmenopausal women. Studies have demonstrated deleterious effects of glitazones on bone metabolism. Glitazones also have direct renal tubular effects increasing sodium reabsorption. We hypothesized that glitazones may also regulate renal calcium excretion.

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