Abdominal Fat Accumulation in Adults Born Preterm Exposed Antenatally to Maternal Glucocorticoid Treatment Is Dependent on Glucocorticoid Receptor Gene Variation | Zendy

Martijn J.J. Finken | Zendy; Ingrid Meulenbelt | Zendy; Friedo W. Dekker | Zendy; Marijke Frölich | Zendy; Frans J. Walther | Zendy; Johannes A. Romijn | Zendy; P. Eline Slagboom | Zendy; Jan M. Wit | Zendy

Open Access

Abdominal Fat Accumulation in Adults Born Preterm Exposed Antenatally to Maternal Glucocorticoid Treatment Is Dependent on Glucocorticoid Receptor Gene Variation

Author(s) -

Martijn J.J. Finken,

Ingrid Meulenbelt,

Friedo W. Dekker,

Marijke Frölich,

Frans J. Walther,

Johannes A. Romijn,

P. Eline Slagboom,

Jan M. Wit

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-0288

Subject(s) - glucocorticoid , glucocorticoid receptor , medicine , endocrinology , gestational age , waist , insulin resistance , insulin , context (archaeology) , prospective cohort study , pregnancy , body mass index , biology , genetics , paleontology

Preterm birth is associated with short stature, abdominal adiposity, insulin resistance, and hypertension, resembling effects of increased glucocorticoid bioactivity. Although antenatal glucocorticoid treatment does not substantially contribute to these associations, it is unknown whether genetic variants in the glucocorticoid receptor gene could modulate the effects of antenatal glucocorticoid treatment on the above phenotype.

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