Open AccessTripartite Control of Dynamic ACTH-Cortisol Dose Responsiveness by Age, Body Mass Index, and Gender in 111 Healthy Adults
Author(s) -
Johannes D. Veldhuis,
Ali Iranmanesh,
Ferdinand Roelfsema,
Paul Aoun,
Paul Y. Takahashi,
John J. Miles,
Daniel M. Keenan
Publication year - 2011
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2011-0084
Subject(s) - potency , medicine , body mass index , endocrinology , adrenocorticotropic hormone , young adult , hormone , biology , in vitro , biochemistry
Recent analyses in small cohorts suggest that pituitary hormones exert time-varying (viz., initial and delayed) dynamic dose-responsive effects on target glands, wherein down-regulating dynamics are inferable on a time scale of single pulses.
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