Nonclassic TSH Resistance:TSHRMutation Carriers with Discrepantly High Thyroidal Iodine Uptake | Zendy

Satoshi Narumi | Zendy; Keisuke Nagasaki | Zendy; Tomohiro Ishii | Zendy; Koji Muroya | Zendy; Yumi Asakura | Zendy; Masanori Adachi | Zendy; Tomonobu Hasegawa | Zendy

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Nonclassic TSH Resistance:TSHRMutation Carriers with Discrepantly High Thyroidal Iodine Uptake

Author(s) -

Satoshi Narumi,

Keisuke Nagasaki,

Tomohiro Ishii,

Koji Muroya,

Yumi Asakura,

Masanori Adachi,

Tomonobu Hasegawa

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-0070

Subject(s) - medicine , endocrinology , mutant , mutation , receptor , thyrotropin receptor , signal transduction , gnas complex locus , chemistry , cancer research , gene , graves' disease , thyroid , biochemistry

Inactivating mutations in the TSH receptor gene (TSHR) cause TSH resistance. Most patients with TSH resistance have low to normal thyroidal radioiodine uptake (RAIU), which is consistent with the physiological knowledge that TSH stimulates iodine uptake. To date, only one TSHR mutation-carrying family with discrepantly high RAIU has been reported.

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