IGF-I Bioactivity Better Reflects Growth Hormone Deficiency than Total IGF-I | Zendy

Aimee J. Varewijck | Zendy; S.W.J. Lamberts | Zendy; P. Uitterlinden | Zendy; Leo J. Hofland | Zendy; J. A. M. J. L. Janssen | Zendy

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IGF-I Bioactivity Better Reflects Growth Hormone Deficiency than Total IGF-I

Author(s) -

Aimee J. Varewijck,

S.W.J. Lamberts,

P. Uitterlinden,

Leo J. Hofland,

J. A. M. J. L. Janssen

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2011-0051

Subject(s) - growth hormone deficiency , growth hormone , endocrinology , medicine , biology , hormone

GH is considered the main regulator of circulating IGF-I. Total (extractable) IGF-I is therefore routinely used for diagnosis of GH deficiency (GHD) and for monitoring treatment. Methods currently used for measurement of circulating total IGF-I may be hampered by interferences of IGF-binding proteins. Recently a kinase receptor activation assay was developed to determine IGF-I bioactivity in human serum. The principle of this assay is based on quantification of IGF-I receptor activation after stimulation with serum in vitro.

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