Effect of Intensive Insulin Therapy on the Somatotropic Axis of Critically Ill Children | Zendy

Marijke Gielen | Zendy; Dieter Mesotten | Zendy; Michael P. Brugts | Zendy; Willy Coopmans | Zendy; Erik Van Herck | Zendy; Ilse Vanhorebeek | Zendy; Robert C. Baxter | Zendy; Steven W. J. Lamberts | Zendy; J. A. M. J. L. Janssen | Zendy; Greet Van den Berghe | Zendy

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Effect of Intensive Insulin Therapy on the Somatotropic Axis of Critically Ill Children

Author(s) -

Marijke Gielen,

Dieter Mesotten,

Michael P. Brugts,

Willy Coopmans,

Erik Van Herck,

Ilse Vanhorebeek,

Robert C. Baxter,

Steven W. J. Lamberts,

J. A. M. J. L. Janssen,

Greet Van den Berghe

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-3045

Subject(s) - medicine , insulin , hypoglycemia , critically ill , context (archaeology) , endocrinology , somatotropic cell , anabolism , intensive care , hormone , pediatric intensive care unit , hydrocortisone , intensive care unit , growth hormone , intensive care medicine , biology , paleontology

Intensive insulin therapy (IIT) improved outcome in the adult and pediatric intensive care unit (PICU) compared with conventional insulin therapy (CIT). IIT did not increase the anabolic hormone IGF-I in critically ill adults, but feeding in critically ill children and pediatric hormonal responses may differ. Twenty-five percent of the children with IIT experienced hypoglycemia, which may have evoked counterregulatory responses.

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