Treatment with Anakinra Improves Disposition Index But Not Insulin Sensitivity in Nondiabetic Subjects with the Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study | Zendy

Edwin J.P. van Asseldonk | Zendy; Rinke Stienstra | Zendy; Tim B. Koenen | Zendy; Leo A. B. Joosten | Zendy; Mihai G. Netea | Zendy; Cees J. Tack | Zendy

Open Access

Treatment with Anakinra Improves Disposition Index But Not Insulin Sensitivity in Nondiabetic Subjects with the Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study

Author(s) -

Edwin J.P. van Asseldonk,

Rinke Stienstra,

Tim B. Koenen,

Leo A. B. Joosten,

Mihai G. Netea,

Cees J. Tack

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-2992

Subject(s) - anakinra , medicine , insulin resistance , endocrinology , placebo , crossover study , adipose tissue , metabolic syndrome , c reactive protein , insulin , inflammation , obesity , pathology , alternative medicine , disease

Obesity induces low-grade inflammation that may promote the development of insulin resistance. IL-1 is one of the key inflammatory factors.

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