Identification of Genetic Alterations ofAXIN2Gene in Adrenocortical Tumors | Zendy

Audrey Chapman | Zendy; Julien Durand | Zendy; Lydia Ouadi | Zendy; Isabelle Bourdeau | Zendy

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Identification of Genetic Alterations ofAXIN2Gene in Adrenocortical Tumors

Author(s) -

Audrey Chapman,

Julien Durand,

Lydia Ouadi,

Isabelle Bourdeau

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-2987

Subject(s) - axin2 , wnt signaling pathway , adrenocortical carcinoma , biology , gene , catenin , cancer research , somatic cell , identification (biology) , mutation , genetics , endocrinology , botany

Mutations of the β-catenin gene (CTNNB1), which lead to constitutive activation of Wnt signaling, have recently been described in adrenocortical adenomas (AA) and carcinomas (ACC). However, somatic CTNNB1 mutations may explain only about 50% of β-catenin accumulation observed in adrenocortical tumors, indicating that other components of the Wnt pathway may be involved.

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