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The human endometrium has an exceptional capacity for repeated repair after menses, but its regulation remains undefined. Premenstrually, progesterone levels fall and prostaglandin (PG) F₂α synthesis increases, causing spiral arteriole constriction. We hypothesized that progesterone withdrawal, PGF₂α, and hypoxia increase vascular endothelial growth factor (VEGF), an endometrial repair factor.

The Regulation of Vascular Endothelial Growth Factor by Hypoxia and Prostaglandin F2αduring Human Endometrial Repair

The Regulation of Vascular Endothelial Growth Factor by Hypoxia and Prostaglandin F_2αduring Human Endometrial Repair