Effects of Physiological Variations in Circulating Insulin Levels on Bone Turnover in Humans | Zendy

Rita Basu | Zendy; James M. Peterson | Zendy; Robert A. Rizza | Zendy; Sundeep Khosla | Zendy

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Effects of Physiological Variations in Circulating Insulin Levels on Bone Turnover in Humans

Author(s) -

Rita Basu,

James M. Peterson,

Robert A. Rizza,

Sundeep Khosla

Publication year - 2011

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2010-2877

Subject(s) - endocrinology , medicine , osteocalcin , insulin , bone remodeling , n terminal telopeptide , bone resorption , osteoprotegerin , carbohydrate metabolism , chemistry , activator (genetics) , alkaline phosphatase , receptor , biochemistry , enzyme

Recent studies in mice have demonstrated that insulin signaling in osteoblasts stimulates bone formation and reduces osteoprotegerin production; the latter results in an increase in bone resorption, which then leads to the release of undercarboxylated osteocalcin from bone. Undercarboxylated osteocalcin, in turn, enhances insulin sensitivity.

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